Composition and method for preventing or treating diseases characterized by abnormal proliferation of fibroblasts and extracellular matrix deposition

• Main Authors: LANDER CYNTHIA, BROPHY COLLEEN
• Format: Patent
• Language: Chinese; English
• Published: 08.05.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compositions and methods for preventing or treating diseases characterized by abnormal proliferation of fibroblasts and extracellular matrix deposition. The present invention provides compositions and methods for preventing or treating diseases, pathologies, or pathological processes characterized by abnormal fibroblast proliferation and extracellular matrix deposition in the tissues of the subject. The method includes administering a therapeutic amount of a pharmaceutical composition comprising a polypeptide having the amino acid sequence YARAAARQARARKALARQLGVAA (SEQ ID NO:1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. 本发明涉及用于预防或治疗以成纤维细胞异常增殖及细胞外基质沉积为特征的疾病的组合物和方法。本发明提供了用于预防或治疗以在受治疗者的组织中异常的成纤维细胞增殖和细胞外基质沉积为特征的疾病、病状或病理过程的组合物和方法。该方法包括施用治疗量的包括具有氨基酸序列YARAAARQARAKALARQLGVAA(SEQ ID NO：1)的多肽或其功能等同物，和药学上可接受的载体的药物组合物。