NEW PROPANAMINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS

• Main Authors: VIRGILI-BERNADO MARINA MARINA, OSORIO-PLANES LAURA, ALONSO-XALMA MONICA, ALMANSA-ROSALES CARMEN
• Format: Patent
• Language: Chinese; English
• Published: 05.05.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to new compounds of general formula (I) that show dual activity towards alpha 2 delta subunit of voltage-gated calcium channels (VGCC), especially the alpha 2 delta-1 subunit, and to the noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments. 本发明涉及新的通式(I)的化合物，其对电压门控钙通道(VGCC)的α2δ亚基，尤其是α2δ-1亚基，和去甲肾上腺素转运蛋白(NET)显示出双重活性。本发明还涉及制备所述化合物的方法以及包含它们的组合物，并且涉及它们作为药物的用途。