METHOD FOR PREDICTING THE RESPONSE OF NON-SMALL-CELL LUNG CARCINOMA PATIENTS TO A MEDICAMENT

• Main Authors: RUIJTENBEEK ROBBY, MATHIJSSEN ADRIANUS, VAN DEN HEUVEL DIRGJE, DE WIJN RICHARD, AERTS JOAN
• Format: Patent
• Language: Chinese; English
• Published: 01.05.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a method for determining or predicting the response of a patient diagnosed with non-small-cell lung carcinoma to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non-small-cell lung carcinoma to specific medicaments. More specifically, the present invention provides methods which measure kinase-activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in blood samples of said patients. 本发明涉及一种用于确定或预测诊断为非小细胞肺癌的患者对靶向药物治疗的反应的方法。本发明还旨在提供预测被诊断为非小细胞肺癌的患者对特定药物的反应的方法和装置。更具体地说，本发明提供了通过研究药物在所述患者的血液样本中引起的磷酸化水平和表达谱及其抑制来测定激酶活性的方法。