RAPAMYCIN DERIVATIVES

• Main Authors: BONAZZI SIMONE, ROGGO SILVIO, PATTERSON ANDREW WILLIAM, SHAVLAKADZE TEA, GLASS DAVID JONATHAN, MIHALIC MANUEL, CONNOLLY MICHAEL
• Format: Patent
• Language: Chinese; English
• Published: 01.05.2020
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of makingcompounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein. 本披露涉及具有式(I)的化合物，和药学上可接受的盐、及其组合物，其中取代基如本文中所定义。还提供制造具有式(I)的化合物的方法，以及涉及所述化合物或组合物用于治疗本文所述的障碍和疾病的方法。