PREPARATION OF SOLID DOSAGE FORMS COMPRISING ANTIBODIES BY SOLUTION/SUSPENSION LAYERING

• Main Authors: BRAVO ROBERTO, VARUM FELIPE, VON ROCHOW LAETITIA, WETZEL CARMEN
• Format: Patent
• Language: Chinese; English
• Published: 01.05.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a method for preparing immediate and sustained release solid dosage forms, comprising antibodies and functional fragments thereof, by solution/suspension layering, optionally coated with a delayed release coating; the solid dosage forms prepared by the method; and the use of the solid dosage forms in the topical treatment in the gastrointestinal tract of a patient. 本发明涉及：一种用于通过溶液/混悬液层积以制备速释和缓释固体制剂的方法，该固体制剂包含抗体及其功能性片段，可选地使用迟释包衣对该速释和缓释固体制剂进行包衣；通过该方法制备的固体制剂；以及该固体制剂在患者胃肠道的局部治疗中的用途。