Sulfonamido-substituted dihydropyrrolidone derivative and preparation method thereof

• Main Authors: ZHENG ANQI, MIAO CHUNBAO, LYU XINYU, YANG HAITAO
• Format: Patent
• Language: Chinese; English
• Published: 01.05.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the field of organic synthesis, and particularly relates to a sulfonamido-substituted dihydropyrrolidone derivative and a preparation method thereof, wherein oxime ester and sulfonamido malonate are used as raw materials and are subjected to a reaction in an organic solvent by using a copper salt as a catalyst and using the oxime ester as an internal oxidant to prepare thesulfonamido-substituted dihydropyrrolidone derivative for the first time. According to the invention, the selected raw materials oxime ester and sulfonamido malonate are simple and easy to obtain; the operation steps are simple; the catalyst is cheap and easily available; the substrate range is wide; the functional group tolerance is good; the final dihydropyrrolidone derivative can be obtained from various substituted oxime esters and sulfonamido malonates at a good yield; and the method has the advantages of high yield, mild reaction conditions, short synthesis route and the like, and has important application valu