Multispecific binding molecules having specificity to dystroglycan and laminin-2
Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding mo...
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Main Authors | , , , , , , , , , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
10.04.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.
本文中提供了多特异性(例如双特异性)结合分子,其包含结合肌营养不良蛋白聚糖的细胞外部分的第一结合结构域和结合层粘连蛋白-2的第二结合结构域。本文中还提供了制备这种结合分子的方法以及这种结合分子用于治疗和/或预防α-肌营养不良蛋白聚糖病的用途。 |
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Bibliography: | Application Number: CN201880013751 |