GEMCABENE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

• Main Authors: BISGAIER CHARLES LARRY, ONICIU DANIELA CARMEN, GOMES JOSE RUI, HECKHOFF STEFAN
• Format: Patent
• Language: Chinese; English
• Published: 10.04.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

This present invention provides gemcabene pharmaceutically acceptable salts having a PSD90 of 35 [mu]m to about 90 [mu]m, methods for purifying crude gemcabene, pharmaceutically acceptable salts of purified gemcabene, pharmaceutical compositions of a gemcabene pharmaceutically acceptable salt and therapeutic and prophylactic methods useful for various conditions, including dyslipidemia. 本发明提供：吉卡宾的药学上可接受的盐，其具有35μm至约90μm的PSD90；用于纯化粗制吉卡宾的方法；纯化的吉卡宾的药学上可接受的盐；吉卡宾的药学上可接受盐的药物组合物；以及，用于各种病况、包括异常脂血症的治疗和预防方法。