Application of 3-site functionalized N(O,S)-heterozygous indene derivative in preparation of anti-Zikavirus drug and pharmaceutical composition

• Main Authors: NIU WEIPING, WANG MINGHUA, ZHANG GUONING, ZHOU HUIYU, ZHU MEI, CEN SHAN, DU XIAONAN, HU SHANGJIU, SHAN QI, DOU YUE, WANG YUCHENG, WANG JUXIAN
• Format: Patent
• Language: Chinese; English
• Published: 07.04.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention, which relates to the technical field of drug application, provides application of a 3-site functionalized N(O,S)-heterozygous indene derivative in preparation of an anti-Zikavirus drugand a pharmaceutical composition. The 3-site functionalized N(O,S)-heterozygous indene derivative has a clear Zikavirus resisting effect and has obvious inhibitory activity on replication of Zikavirus. The preliminary toxicity research shows that the derivative has high druggability and thus the derivative has the broad application prospects as an antiviral drug. 本发明提供了一种3-位官能团化的N(O,S)-杂茚类衍生物在制备抗寨卡病毒药物中的应用、药物组合物，涉及药物应用技术领域。本发明所述3-位官能团化的N(O,S)-杂茚类衍生物具有明确的抗寨卡病毒作用，对寨卡病毒的复制具有明显的抑制活性；初步毒性研究显示其具有良好的成药性，表明该类衍生物作为抗病毒药物具有良好应用前景。