Pegylated polypeptide prodrug synthesis technology based on photo-regulation, and purpose of pegylated polypeptide prodrug synthesis technology for preparing antimicrobial drug

The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis technology for photosensitive compounds cGS-mPEG and cIN-mPEG, and a purpose of the synthesis technology for preparing an antimicrobial drug. 4'-hydroxyl-3'-methoxyacetophenone is taken as a s...

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Bibliographic Details
Main Authors HU CHENGFEI, JIN YI, WAN YANG, GUAN QINKUN, WEN QUAN
Format Patent
LanguageChinese
English
Published 03.04.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention belongs to the field of medicine synthesis, and particularly relates to a synthesis technology for photosensitive compounds cGS-mPEG and cIN-mPEG, and a purpose of the synthesis technology for preparing an antimicrobial drug. 4'-hydroxyl-3'-methoxyacetophenone is taken as a starting material to prepare a photosensitive radical (2-nitrobenzyl, NB), then, the photosensitive radical isintroduced to a side chain amino position to pre-prepare photosensitive ornithine and lysine; and through solid phase peptide synthesis, antimicrobial peptides Gramicidin S (GS) and Indolicidin (IN) containing the photosensitive radical are prepared. Connection of the peptide and monomethoxy polyethyleneglycol (mPEG) is realized through a strategy of (click reaction). The mPEG is substituted through azides, and then, the click reaction is carried out with the alkyne of the photosensitive radical so as to connect the peptide with the mPEG to prepare cGS-mPEG and ccIN-mPEG. Before the category of compounds is not irradi
Bibliography:Application Number: CN202010029395