Fructose-6-phosphate aldolase variants for aldol carboligations

The invention provides new and alternative fructose-6-phosphate aldolase (FSA) variants which enable the production of optically active building blocks with high chemoselectivity and stereoselectivityusing aldehydes as starting material in aldol carboligation reactions, while avoiding the by-product...

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Main Authors JUNKER SEBASTIAN, ROLDAN GARCIA RAQUEL, FESSNER WOLF-DIETER, DOMINGUEZ DE MARIA PABLO, CLAPES SABORIT PEDRO, BUJONS VILAS JORGE, JOGLAR TAMARGO JESUS
Format Patent
LanguageChinese
English
Published 31.03.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention provides new and alternative fructose-6-phosphate aldolase (FSA) variants which enable the production of optically active building blocks with high chemoselectivity and stereoselectivityusing aldehydes as starting material in aldol carboligation reactions, while avoiding the by-product formation and subsequent reactions. 本发明提供新的和可替代的果糖-6-磷酸醛缩酶(FSA)变体，其能够在羟醛缩合碳连接反应中使用醛作为原料来制备具有高化学选择性和立体选择性的光学活性结构单元，同时避免副产物的形成和后续反应。
Bibliography:Application Number: CN201880032158