Bioactive polypeptide RDLDAPDDVDFF and preparation method and application thereof

• Main Authors: ZHANG SHAOHUI, ZHANG BOYU, FAN MENGZHU, GUO TINGTING, ZHAN WENJING, LUAN YUANYUAN, LI JINTAO, LI MINGYI
• Format: Patent
• Language: Chinese; English
• Published: 31.03.2020
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention relates to the field of protein, in particular to bioactive polypeptide RDLDAPDDVDFF and a preparation method and application thereof. The amino acid sequence of the bioactive polypeptide RDLDAPDDVDFF is Arg-Asp-Leu-Asp-Ala-Pro-Asp-Asp-Val-Asp-Phe-Phe. The in vitro anti-inflammatory activity experiment and in vivo anti-ageing experiment verify that the polypeptide RDLDAPDDVDFF has better anti-inflammatory functions and better anti-ageing activity, on one hand, the bioactive polypeptide RDLDAPDDVDFF can promote macrophagocyte to increase nitric oxide generation inducing quantity,can increase the capacity of organisms for resisting outside pathogen infection, and can reduce the attack rate of the organisms; and on the other hand, the bioactive polypeptide RDLDAPDDVDFF has better anti-ageing activity, can increase the reproduction capacity of nematode, can increase the quality of life, and has quite important significance in development of foods, health-care products and medicines, having anti-infl