Citicoline injection and preparation method thereof

• Main Authors: HU XIANDE, LIAO NIANSHENG, ZOU MINGMING
• Format: Patent
• Language: Chinese; English
• Published: 31.03.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of injections, and particularly provides a citicoline injection and a preparation method thereof, the citicoline injection comprises citicoline, water for injectionand a pH regulator; wherein the pH regulator is an acidic medium and/or an alkaline medium, and the pH of the injection is 6.5-8.0; and BFS sterile filling and sealing are adopted for preparation. Thewater for injection is directly prepared for water temperature control, sterile filling is adopted, final sterilization is not adopted, and related substances of the product can be effectively controlled. Meanwhile, activated carbon is used for adsorption, two-stage filtration of 0.45 micron and 0.2 micron is preferably used, and finally split charging is performed in an A-stage environment, so that the quantity of microorganisms in a liquid medicine can be effectively reduced, and the sterility of the product is ensured. 本发明属于注射液领域，具体提供一种胞二磷胆碱注射液及其制备方法，所述注射液包括胞二磷胆碱、注射用水和pH调节剂；所述pH调节剂为酸性介质和/或碱性介质，所述注射液的pH在6.5-8.0之间；并采