Method for improving preservation quality of ischemia reperfusion organ or composite tissue graft

• Main Authors: CHEN QIAN, NING JIAOLIN, ANDREW J.T. GEORGE, MA DAQING, GU JIATENG, ZHAO HAILIN, LU KAIZHI
• Format: Patent
• Language: Chinese; English
• Published: 31.03.2020
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The invention relates to the technical field of ischemia reperfusion organ grafting and preservation, and discloses method for improving preservation quality of an ischemia reperfusion organ or a composite tissue graft. Dexmedetomidine and/or xenon and/or argon are added into a conventional organ graft preservation liquid to exert a protection function of an organ graft. In a specific embodiment,the method has functions of reducing oxidative stress and inhibiting activation of related tissue cell necrosis paths. 本发明专利涉及缺血再灌注后器官移植保存技术领域，公开了一种提高缺血再灌注后器官或复合组织移植物保存质量的方法，用于通过在常规器官移植物保存液中加用右美托咪定和/或氙和/或氩发挥器官移植物的保护作用。在一个特定的实施方案中，本发明专利的作用在于减少氧化应激和抑制相关组织细胞坏死途径的激活。