RECOMBINANT FOLLISTATIN-FC FUSION PROTEINS AND USE IN TREATING DUCHENNE MUSCULAR DYSTROPHY

The present invention provides, among other things, methods and compositions for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD). In some embodiments, a method accordingto the present invention includes administering to an individual who is suffering from or susceptible...

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Bibliographic Details
Main Authors NORTON ANGELA W, RONG HAOJING, SHEN CHUAN, PAN CLARK, ISKENDERIAN ANDREA
Format Patent
LanguageChinese
English
Published 24.03.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides, among other things, methods and compositions for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD). In some embodiments, a method accordingto the present invention includes administering to an individual who is suffering from or susceptible to DMD an effective amount of a recombinant follistatin fusion protein such that at least one symptom or feature of DMD is reduced in intensity, severity, or frequency, or has delayed onset. 本发明尤其提供了用于治疗肌营养不良，特别是杜氏肌营养不良(DMD)的方法和组合物。在一些实施方案中，根据本发明的方法包括向患有DMD或对DMD敏感的个体施用有效量的重组卵泡抑素融合蛋白，使得DMD的至少一种症状或特征在强度、严重性或频率方面降低，或延迟发作。
Bibliography:Application Number: CN201880045571