Bioactive polypeptide RISLPLPTFSSL and preparation method and application thereof

• Main Authors: ZHANG SHAOHUI, ZHANG BOYU, FAN MENGZHU, GUO TINGTING, ZHAN WENJING, LUAN YUANYUAN, PENG XIAOJIE
• Format: Patent
• Language: Chinese; English
• Published: 24.03.2020
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention relates to the field of protein, in particular to bioactive polypeptide RISLPLPTFSSL and a preparation method and application thereof. The amino acid sequence of the bioactive polypeptide RISLPLPTFSSL is Arg-Ile-Ser-Leu-Pro-Leu-Pro-Thr-Phe-Ser-Ser-Leu. An in-vitro anti-inflammatory activity experiment and an in-vivo anti-aging experiment prove that the polypeptide RISLPLPTFSSL has arelatively good anti-inflammatory function and anti-aging activity. On the one hand, the bioactive polypeptide RISLPLPTFSSL disclosed by the invention can promote the capacity of increasing the induction amount of nitric oxide in macrophages, improve the capacity of resisting external pathogen infection of an organism and reduce the morbidity of the organism; and on the other hand, the active polypeptide has good anti-aging activity, can remove free radicals in the body and improve the quality of life, and has very important significance for developing food, health care products and medicineswith anti-inflammatory and