Preparation method of 2-phosphonothioflavone compound

The invention discloses a preparation method of a 2-phosphonothioflavone compound, which is a method for synthesizing the 2-phosphonothioflavone compound by utilizing water phase visible light catalysis. According to the invention, tetrazole m-dibenzonitrile (4-CzIPN) is used as a photosensitizer, l...

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Bibliographic Details
Main Authors YU BING, LIU YAN, LIU XIAOCENG, PAN YAN, SHANG TIANYI, CHEN ZHONG, SUN KAI, YANG JUNJIE
Format Patent
LanguageChinese
English
Published 24.03.2020
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a preparation method of a 2-phosphonothioflavone compound, which is a method for synthesizing the 2-phosphonothioflavone compound by utilizing water phase visible light catalysis. According to the invention, tetrazole m-dibenzonitrile (4-CzIPN) is used as a photosensitizer, lauroyl peroxide is used as an oxidizing agent, 2-methylthiophenyl propynone and diarylphosphine oxide are used as initial raw materials, water is used as a solvent, and under the protection of nitrogen, an illumination reaction is carried out at room temperature for 24 hours to obtain a target product. The invention provides a method for preparing the 2-phosphonothioflavone compound through water-phase photocatalysis of radical series cyclization reaction for the first time. Compared with a traditional method, according to the method, traditional precious metal (such as ruthenium and iridium) organic photosensitizers do not need to be used, the 2-phosphonothioflavone compound is rapidly andefficiently synthesized u
Bibliography:Application Number: CN201911097576