Disulfide substitute of somatostatin and preparation method for disulfide substitute of somatostatin

• Main Authors: FANG GEMIN, ZHU MANZHOU, MENG XIANGMING, ZHU LIANGJING
• Format: Patent
• Language: Chinese; English
• Published: 20.03.2020
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The invention discloses a disulfide substitute of somatostatin and a preparation method for the disulfide substitute of the somatostatin. The disulfide substitute of the somatostatin is obtained through replacing a disulfide bond of the somatostatin with a thioether bond to obtain a disulfide substitute of the somatostatin, achieving a target polypeptide through an Fmoc solid-phase synthesis method, and subjecting a crude product to purifying and freeze-drying. Compared with the somatostatin, the disulfide substitute of the somatostatin, disclosed by the invention, has good reduction stabilityunder the condition of reduction of dithiothreitol. 本发明公开了一种生长抑素的二硫替代物及其制备方法，通过使用硫醚键替换生长抑素二硫键后得到一种生长抑素二硫替代物，目标多肽是通过Fmoc固相合成方法实现，粗品经纯化，冻干得到生长抑素二硫替代物。本发明的生长抑素二硫替代物相比于生长抑素在二硫苏糖醇还原条件下具有良好的还原稳定性。