Benzoxazole derivative, and preparation method and application thereof

The invention provides a benzoxazole derivative, and a preparation method and an application thereof. The benzoxazole derivative provided by the invention, as a P2Y14 inhibitor, has relatively good inhibitory activity and anti-inflammatory activity; furthermore, research finds that the benzoxazole d...

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Bibliographic Details
Main Authors HU QINGHUA, LI HUANQIU, WANG WEIWEI, SONG JIATAO
Format Patent
LanguageChinese
English
Published 17.03.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a benzoxazole derivative, and a preparation method and an application thereof. The benzoxazole derivative provided by the invention, as a P2Y14 inhibitor, has relatively good inhibitory activity and anti-inflammatory activity; furthermore, research finds that the benzoxazole derivative also has good activity on P2Y14 receptor related hyperuricemia and acute gouty arthritis,and can be used as a medicine for treating hyperuricemia and acute gouty arthritis. 本发明提供了苯并恶唑衍生物及其制备方法和应用，本发明提供的苯并恶唑衍生物作为PY抑制剂具有较好的抑制活性和抗炎活性，进而通过研究发现，其对P2Y14受体相关的高尿酸血症以及急性痛风性关节炎也有很好的活性，可以作为治疗高尿酸血症以及急性痛风性关节炎的药物。
Bibliography:Application Number: CN201911188971