Preparation method of metformin hydrochloride rapid-release preparation

• Main Authors: CAO XINXIN, LIN GUANTONG, SUN YONGXI, LUO XIAOQIAN, LIN XIANGYU, MAO CHUANWEI
• Format: Patent
• Language: Chinese; English
• Published: 13.03.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of medicine and specifically discloses a preparation method of a metformin hydrochloride rapid-release preparation. The preparation method comprises the following steps: 1) sieving, 2) mixing evenly, 3) extruding, 4) crushing, 5) granulating, 6) tabletting, and 7) packaging. The preparation method of the invention is simple and feasible, has the advantages of low energy consumption, no solvent residue and no introduction of other impurities in the whole process, and is easy to realize large-scale industrial production. 本发明属于医药技术领域，具体公开了盐酸二甲双胍速释制剂的制备方法，其包括如下步骤：1）过筛，2）混匀，3）挤压，4）粉碎，5）制粒，6）压片，7）包装。本发明制备方法简单可行，能耗小，无溶剂残留，整个过程不会引入其它杂质，易于实现规模化工业生产。