用于减少肝脏脂肪的3-羟基丁酸化合物

本发明提供了用于减少受试者的肝脏脂肪的化合物，其中所述化合物选自：(i)(R)-3-羟基丁酸；(ii)(R)-3-羟基丁酸的酯；和(iii)可通过聚合(R)-3-羟基丁酸部分获得的低聚物；或其药学上可接受的盐或溶剂化物。所述化合物在患有脂肪肝的受试者中特别有用。所述化合物可以用于治疗非酒精性脂肪性肝病(NAFLD)、非酒精性脂肪性肝炎(NASH)、酒精性脂肪性肝炎(ASH)或非酒精性脂肪肝(NAFL)。 The present invention provides a compound for use in reducing liver fat in a subject, wherein th...

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Bibliographic Details
Format Patent
LanguageChinese
Published 11.06.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:本发明提供了用于减少受试者的肝脏脂肪的化合物，其中所述化合物选自：(i)(R)-3-羟基丁酸；(ii)(R)-3-羟基丁酸的酯；和(iii)可通过聚合(R)-3-羟基丁酸部分获得的低聚物；或其药学上可接受的盐或溶剂化物。所述化合物在患有脂肪肝的受试者中特别有用。所述化合物可以用于治疗非酒精性脂肪性肝病(NAFLD)、非酒精性脂肪性肝炎(NASH)、酒精性脂肪性肝炎(ASH)或非酒精性脂肪肝(NAFL)。 The present invention provides a compound for use in reducing liver fat in a subject, wherein the compound is selected from:(i) (R)-3-hydroxybutyrate;(ii) an ester of (R)-3-hydroxybutyrate; and(iii) an oligomer obtainable by polymerising (R)-3-hydroxybutyrate moieties;or a pharmaceutically acceptable salt or solvate thereof. The compound is particularly useful in subjects suffering from a fatty liver. The compound can be used to treat non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH) or non-alcoholic fatty liver (NAFL).
Bibliography:Application Number: CN20188042880