Oxygen-containing heterocyclic substituted azole compound and applications thereof

• Main Authors: XIANG LI, HENG HAO, CHEN YADONG, WANG SHUXIAN, QIN TIANREN, LU SHUAI, WANG ZHIJIE, TIAN JIEYI, CAI JIONGHENG, LU TAO
• Format: Patent
• Language: Chinese; English
• Published: 25.02.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of medicinal chemistry, and discloses an oxygen-containing heterocyclic substituted azole compound and applications thereof, and specifically relates to an oxygen-containing heterocyclic substituted azole compound and a preparation method thereof, a pharmaceutical composition containing the oxygen-containing heterocyclic substituted azole compound, and medical applications of the oxygen-containing heterocyclic substituted azole compound and the pharmaceutical composition, particularly applications as FMS-like tyrosine kinase 3 inhibitors. 本发明涉及药物化学领域，公开了含氧杂环取代唑类化合物及其用途。具体涉及含氧杂环取代唑类化合物、它们的制备方法、含有这些化合物的药用组合物以及它们的医疗用途，特别是作为FMS样酪氨酸激酶3抑制剂的用途。