Application of sesquiterpenoids in preparation of medicine for treating gastrointestinal stromal tumor

• Main Authors: TIAN ZHILEI, LI FEI
• Format: Patent
• Language: Chinese; English
• Published: 14.02.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides application of sesquiterpenoids in preparation of a medicine for treating gastrointestinal stromal tumor. Didingsu B, aristolactone and versicolactone B all have an inhibiting effect on gastrointestinal stromal tumor. The compound disclosed by the invention is low in toxicity and small in side effect, has a good effect of inhibiting gastrointestinal stromal tumor, expands the drug range for treating gastrointestinal stromal tumor, and has the characteristics of good stability, rapid release and improved drug activity. 本发明提供一种倍半萜类化合物在制备治疗胃肠间质瘤药物中的用途，其中地丁素B、aristolactone、银袋内酯乙均对胃肠间质瘤具有抑制作用。本发明化合物毒性低，副作用小，具有良好的抑制胃肠间质瘤的效果，扩展了治疗胃肠间质瘤的药物范围，具有稳定性好，释放迅速，提高了药物活性的特点。