Vitamin D loaded calcium citrate/calcium sulfate composite bone cement and preparation method

• Main Authors: DENG GUANGJIN, JI MIZHI, CHEN HONG, YAN YONGGANG
• Format: Patent
• Language: Chinese; English
• Published: 07.02.2020
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention belongs to the field of bone repairing materials, and particularly relates to vitamin D loaded calcium citrate/calcium sulfate composite bone cement, a preparation method and an application. The invention provides the vitamin D loaded calcium citrate/calcium sulfate composite bone cement which consists of a solid phase part and a liquid phase part, wherein a liquid-to-solid ratio is(0.2-0.6):1; the solid phase part comprises calcium citrate, calcium sulfate and vitamin D; a mass ratio of calcium citrate to calcium sulfate is 1:4-4:1; and a mass ratio of the vitamin D to the bonecement is (6*10<-3>-20*10<-3>):1. The composite bone cement has good injectability, appropriate solidification time, slow medicine release and excellent bioactivity and can be used for filling of bone defects. 本发明属于骨修复材料领域，具体涉及一种载维生素D的柠檬酸钙/硫酸钙复合骨水泥及制备方法与应用。本发明提供一种负载维生素D的柠檬酸钙/硫酸钙复合骨水泥，所述骨水泥由固相部分和液相部分组成，液固比为0.2～0.6：1；固相部分包括柠檬酸钙、硫酸钙盐和维生素D，柠檬酸钙和硫酸钙盐的质量比为1：4～4：1；维生素D与骨水泥的质量比为6×10～20×10：1。本发明所得复合骨水泥具有良好的可注射性、合适的凝固时间、缓慢的药物释放和优异的