Long-acting drug-loaded fat emulsion preparation and preparation method thereof

• Main Authors: DU SONG, LAN JINGDONG, YUE FENG, CAI WENJIAN, ZHONG LENG, FANG ZHIFENG
• Format: Patent
• Language: Chinese; English
• Published: 24.01.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention discloses a long-acting drug-loaded fat emulsion preparation, which comprises the following components in percentage by mass: 0.5-10% of phospholipid or fatty acid of polyethylene glycol, 0.6-20% of an emulsifier, 0.5-10% of a solubilizer, 0-6% of a co-emulsifier, 8-30% of oil for injection, 2-8% of an isotonic agent and the balance of water for injection. According to the fat emulsion preparation prepared by the invention, the prescription is changed, the particle size is reduced, the fat emulsion preparation is suitable for medicines which are easy to damage at high temperature, the solvent dissolving step is added, and the fat emulsion preparation is suitable for medicines which can be dissolved in solvents and are insoluble in water or oil; phospholipid or fatty acid of polyethylene glycol is increased, and an in-vivo long-acting effect is achieved. The stability of the injection is improved, the drug effect of the preparation is improved, the safety of the drug is guaranteed, the preparatio