用心肌肌钙蛋白I和早期生物标记物帮助诊断和评价人受试者中轻度创伤性脑损伤的方法

• Format: Patent
• Language: Chinese
• Published: 26.04.2024
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

本文公开了通过以下帮助诊断和评价已遭受或可能已遭受头部损伤、诸如轻度或中度、重度、或中度至重度创伤性脑损伤(TBI)的人类受试者的方法：检测在所述受试者已遭受或可能已遭受所述头部损伤之后约24小时内的时间点取自人类受试者的生物样品中的心肌肌钙蛋白I(cTnI)和不是cTnI的一种或多种早期生物标记物、诸如泛素羧基末端水解酶L1(UCH-L1)、胶质细胞原纤维酸性蛋白(GFAP)或其组合的水平。 Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using cTnI. Also disclosed are methods for determining whether to perform a head computerized tomography on a subject by detecting levels of cTnI. Finally, also disclosed are methods of outcome in subjects suffering from a mild TBI.