增强免疫反应的组合物及方法

• Format: Patent
• Language: Chinese
• Published: 08.12.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

本发明提供一种医药组合物，包含一抗原融合蛋白，该抗原融合蛋白包含一抗原及一Fcγ受体拮抗分子。本发明亦提供一种增强抗原的免疫原性的方法，包含将该抗原与一Fcγ受体拮抗分子相连接以形成一抗原融合蛋白。本发明亦提供一种增强个体对一抗原的免疫反应的方法，包含施予该个体有效量的一包含抗原及Fcγ受体拮抗分子的抗原融合蛋白。本发明可应用于开发强效疫苗，此基于通过与Fcγ受体结合而将疫苗抗原靶向至抗原呈献细胞。 Provided is a pharmaceutical composition, including an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. Also provided is a method of enhancing immunogenicity of an antigen, including conjugating the antigen with an antagonist of an Fc gamma receptor to form an antigen fusion protein. Also provided is a method of enhancing an immune response to an antigen in a subject, including administering to the subject an effective amount of an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. The present invention may be applied in the development of potent vaccines based on targeting vaccine antigens to antigen-presenting cells via binding to Fc gamma receptors.