Method for detecting related substances in simethicone

• Main Authors: LU YING, LIN DONGQIAO, SHEN MEILIAN, YANG XI, PENG JING, LI SHAN, WANG ZHONGDA, ZHANG GUANGCAI
• Format: Patent
• Language: Chinese; English
• Published: 14.01.2020
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The application discloses a method for detecting related substances in simethicone. Simethicone is pretreated; and related substances in the simethicone are effectively detected by adopting a gas chromatography method. The method is simple to operate; the impurity peak and the adjacent peak realize baseline separation; the peak shape is good; and the reproducibility is high. The blank of detectionof related substances in the simethicone quality standard is effectively filled; a technical reference can be provided for simethicone quality control; and the medication safety is ensured. 本申请公开了一种检测西甲硅油中有关物质的方法。通过对西甲硅油进行前处理，采用气相色谱法，有效地检测出了西甲硅油中的有关物质。该方法操作简单，杂质峰与相邻峰达到了基线分离，峰形较好，重现性好，并有效填补了西甲硅油质量标准中有关物质检测的空白，可对西甲硅油质量控制提供技术参考，保证用药安全。