Determination method of polyethylene glycol 4000 content in compound polyethylene glycol electrolyte powder

• Main Authors: ZHOU HAIYAN, BAI XIAOHONG, TANG JIANZHEN
• Format: Patent
• Language: Chinese; English
• Published: 10.01.2020
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention provides a determination method of polyethylene glycol 4000 content in compound polyethylene glycol electrolyte powder. According to the method, a high-performance liquid chromatographicmethod and a differential refractive index detector are adopted, a hydrogel chromatographic column, namely a Plaquagel-OH column is used as the chromatographic column, an appropriate salty solution is selected to serve as a mobile phase, and an isocratic elution mode is adopted. The method is convenient and feasible to use, high in precision, accurate in detection result and good in repeatabilityand recovery rate; and through verification, the method can be used for detecting the polyethylene glycol 4000 content in the compound polyethylene glycol electrolyte powder. 本发明提供一种复方聚乙二醇电解质散中聚乙二醇4000含量的测定方法，该方法采用高效液相色谱法，采用示差折射率检测器，以水相凝胶色谱柱Plaquagel-OH柱为色谱柱，选用了适当的有盐溶液为流动相，采用等度洗脱方式。本方法简便可行，精密度高，检测结果准确，重复性和回收率良好，且该方法通过验证，可以用来检测复方聚乙二醇电解质散中聚乙二醇4000含量。