N-(2-ethylamine) benzenesulfonamide cordycepin derivative as well as preparation method and application thereof

The invention discloses an N-(2-ethylamine) benzenesulfonamide cordycepin derivative as well as a preparation method and an application thereof in inhibiting tumor cell proliferation, and the N-(2-ethylamine) benzenesulfonamide cordycepin derivative is prepared by chemically modifying cordycepin. Co...

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Bibliographic Details
Main Authors CHEN FANG, NIU CHUN, LI YONG, SHI WANQI, CAO TINGTING, YANG ZIYAO
Format Patent
LanguageChinese
English
Published 10.01.2020
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The invention discloses an N-(2-ethylamine) benzenesulfonamide cordycepin derivative as well as a preparation method and an application thereof in inhibiting tumor cell proliferation, and the N-(2-ethylamine) benzenesulfonamide cordycepin derivative is prepared by chemically modifying cordycepin. Compared with cordycepin, the N-(2-ethylamine) benzenesulfonamide cordycepin derivative shows better activity on proliferation inhibition of MDA-MB-231 cells, A549 cells and HeLa cells. 本发明公开了一种N-(2-乙基胺)苯磺酰胺基虫草素衍生物及其制备方法和在抑制肿瘤细胞增殖方面的应用，通过对虫草素进行化学改性，制备出的N-(2-乙基胺)苯磺酰胺基虫草素衍生物。相对于虫草素，N-(2-乙基胺)苯磺酰胺基虫草素衍生物对MDA-MB-231、A549和HeLa细胞的增值抑制表现出更好活性。
Bibliography:Application Number: CN201810720060