Novel microtube reaction technology for synthesizing metronidazole bulk drug, and application thereof

• Main Authors: ZHANG ZHENYU, ZHAO TAOTAO, WU CHENGCHENG, HU QUANYUAN
• Format: Patent
• Language: Chinese; English
• Published: 10.01.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of medicine manufacturing, and particularly relates to a novel microtube reaction technology for synthesizing a metronidazole bulk drug, and an applicationthereof. The novel production technology is provided to overcome the defects of existing industrial production technologies of metronidazole. The technology mainly comprises the following steps: preparing a high-concentration mixed acid solution of 2-methyl-5-nitroimidazole under a high-temperature condition, wherein the mixed acid is a mixed solution of formic acid and concentrated sulfuric acid; respectively and simultaneously feeding the mixed acid solution and ethylene oxide into a miniature coil pipe, performing a reaction, and placing the miniature coil pipe in a 90-95 DEG C liquid medium; carrying out reduced pressure distillation to obtain a reaction concentrate; diluting the reaction concentrate, neutralizing the reaction concentrate until the pH value is 2.0-2.5, and cooling andfiltering the neutralized