Lornoxicam freeze-dried orally disintegrating tablet and preparation method thereof

• Main Authors: WEN YUELAN, ZHANG JIAHUAN, CAIN GUANGZI, WEN JIE, CHEN JINJING
• Format: Patent
• Language: Chinese; English
• Published: 07.01.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a lornoxicam freeze-dried orally disintegrating tablet and a preparation method thereof. The lornoxicam freeze-dried orally disintegrating tablet consists of lornoxicam and a matrix, wherein the single dosage effective component lornoxicam is 4-10mg; and the matrix comprises 0.8-10mg of an adhesive, 10-200mg of a framework support agent, 0-10mg of a flavoring agent and 0-10mg of an essence. The preparation method of the lornoxicam freeze-dried orally disintegrating tablet provided by the invention comprises steps of dissolution, mold injection, quick freezing, freeze-drying and product packaging. The lornoxicam freeze-dried orally disintegrating tablet provided by the invention is simple and convenient to take and rapid to disintegrate, can be dissolved immediately after being orally taken, can be directly taken without water and is rapid to absorb, and a first pass effect can be avoided. 本发明提供了一种氯诺昔康冻干口崩片及其制备方法。该氯诺昔康冻干口崩片是由氯诺昔康与基质组成，其中单剂量有效成分氯诺昔康为4mg～10mg，基质含有粘合剂0.8mg～10mg、骨架支撑剂10mg～20