Temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material and preparation method thereof

• Main Authors: DENG GUANGJIN, JI MIZHI, YAN YONGGANG
• Format: Patent
• Language: Chinese; English
• Published: 03.01.2020
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention discloses a temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material. The temperature and modulus dual-controlled nano-hydroxyapatiteand polyamino acid composite bone graft material is formed by polyamino acid and nano-hydroxyapatite in an in-situ composting mode, and the structure of the temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material is shown as a formula (I) (please see the specifications for the formula (I)). The invention further provides a preparation method andapplication of the composite bone graft material. The temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material comprising a bionic structure and prepared through the preparation method has the mechanical property approaching to that of human bones and has the deformation temperature and elasticity modulus which can be adjusted and controlled; secondary modeling is easy t