DNA METHYLATION AND MUTATIONAL ANALYSIS METHODS FOR BLADDER CANCER SURVEILLANCE

• Main Authors: KNEZEVIC DEJAN, LOPATIN MARGARITA, MILLER DAVID P, SILK CHRISTOPHER N, TSIATIS ATHANASIOS, CRAGER MICHAEL, FEBBO PHILLIP
• Format: Patent
• Language: Chinese; English
• Published: 27.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence. 本申请涉及监测膀胱癌患者并且分析患者样品中甲基化DNA和任选的特定基因突变的存在的方法。在一些实施方案中，分析结果与临床结果指标(例如膀胱癌复发的风险)相关。