Application of chlorogenic acid in inhibition of intracellular c-di-GMP high expression movement of pseudomonas aeruginosa

• Main Authors: XIE JIEPENG, LI DONGMEI, KONG JINLIANG, WANG KE
• Format: Patent
• Language: Chinese; English
• Published: 20.12.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of chlorogenic acid in inhibition of intracellular c-di-GMP high-expression movement of pseudomonas aeruginosa, and particularly provides an inhibition method and a concentration of chlorogenic acid. The invention proves that the chlorogenic acid can inhibit the intracellular c-di-GMP high expression of the pseudomonas aeruginosa so as inhibit the movement ofthe pseudomonas aeruginosa. According to the invention, the movement of pseudomonas aeruginosa can be inhibited, and a basis is provided for searching a drug action target for effectively interveningpseudomonas aeruginosa. 本发明公开了绿原酸在抑制铜绿假单胞菌胞内c-di-GMP高表达运动中的应用，并具体提供了抑制方法和绿原酸的浓度。本发明证明了绿原酸能够抑制铜绿假单胞菌胞内c-di-GMP高表达，从而抑制铜绿假单胞菌的运动。通过本发明能够抑制铜绿假单胞菌的运动，并且为寻找有效干预铜绿假单胞菌的药物作用靶点提供依据。