New application of liquorice

• Main Authors: HE YUFEI, LI YAZHUO, ZHOU HUA, CI XIAOYAN, ZENG YONG, XIE YING, LIU CHANGXIAO, YI XIULIN
• Format: Patent
• Language: Chinese; English
• Published: 17.12.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an induction effect of active ingredients including liquiritin, liquiritigenin, isoliquiritin, isoliquiritigenin, chalcone A and glycyrrhetinic acid in two major categories offlavonoids and pentacyclic triterpenoids in liquorice on an efflux transporter P-gp. According to the invention, the mRNA expression, the protein expression and the efflux transport function of P-gp in cells after drug administration are mainly researched to confirm that the active ingredients in liquorice have the induction effect on P-gp. The invention provides a foundation for reasonable application of medicine compatibility and clinical pharmacological research, provides a basis for further understanding of the liquorice detoxification mechanism, and is of important significance for safe and effective clinical medication. 本发明公开甘草中黄酮类和五环三萜类两大主要类别中的活性成分甘草苷，甘草素，异甘草苷，异苷草素，查尔酮A和甘草次酸对外排转运体P-gp的诱导作用。主要通过研究给药后细胞中P-gp的mRNA表达，蛋白表达，和外排转运功能，确认了甘草中的活性成分对P-gp具有诱导作用。为药物配伍合理应用和临床药理研究提供了基础，为进一步理解甘草解毒机制提供了依据，并对临床上安全、有效用药具有重要的意义