Sulfonamide compound, preparation method and medical application thereof

• Main Authors: YIN HUIJUN, SHI JIANXIN, ZONG LIBIN, SI CHUNFENG, SUN RONGHUA, LIU CHUNYAN, YAN XU, MI ZHEN, WANG BIN
• Format: Patent
• Language: Chinese; English
• Published: 13.12.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a sulfonamide compound, a preparation method and medical application thereof. Specially, the invention relates to a compound shown as a general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound, and application thereof as an agonist of farnesoid X receptor (FXR). The compound and the pharmaceutical composition containing the compound can be used for treating and/or preventing diseases associated with FXR activity, such as cholestatic disorders, diabetes and complications thereof, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatosis heptitis (NASH), obesity or metabolic syndromes (dyslipidemia, diabetes and combined disorders with abnormally high body mass indexes) and cardiovascular diseases. The definitions of each substituent in the general formula (I) are the same as those in the specification. 本发明涉及磺酰胺类化合物及其制备方法和医药用途。特别地，本发明涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物，及其作为法尼醇衍生物X受体(Farnesoid X receptor，FXR)激动剂的用途，该化合物及含有该化合物的药物组合物可以用