CHEMOKINE CXCR4 RECEPTOR MODULATORS AND USES RELATED THERETO

• Main Authors: LIOTTA DENNIS C, KIM MICHELLE BORA, TAHIROVIC YESIM ALTAS, TRUAX VALARIE, JECS EDGARS, MILLER ERIC JAMES, WILSON ROBERT JAMES, WILSON LAWRENCE, KAISER THOMAS, NGUYEN HUY HOANG
• Format: Patent
• Language: Chinese; English
• Published: 06.12.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compoundsor pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent. 本公开内容涉及趋化因子CXCR4受体调节剂及其相关用途。该受体调节剂可以被配制以形成包含所公开的化合物或其药学上可接受的盐或前药的药物组合物。该组合物可以被用于控制CXCR4相关的状况，通常是预防或治疗病毒感染、异常细胞增殖、视网膜退化(retinal degeneration)、炎性疾病，或作为免疫刺激剂或免疫抑制剂，或用于控制癌症并且可以与另一种活性成分诸如抗病毒剂或化学治疗剂一起施用。