Process of producing N-alkylacetamides

There is disclosed a process of producing an N-alkylacetamide of the general formula (III): wherein X , X and X are the same or different and are independently hydrogen, lower alkyl, lower alkoxy, lower alkenyl, halogen or trifluoromethyl; R and R are the same or different and are independently lowe...

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Bibliographic Details
Main Authors KATUHISA MASUMOTO, AKIHIKO NAKAMURA, YUJIRO KIYOSHIMA
Format Patent
LanguageEnglish
Published 19.07.1995
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:There is disclosed a process of producing an N-alkylacetamide of the general formula (III): wherein X , X and X are the same or different and are independently hydrogen, lower alkyl, lower alkoxy, lower alkenyl, halogen or trifluoromethyl; R and R are the same or different and are independently lower alkyl; and @ represents a chemical bond of E- or Z-configuration, or a mixture of these configurations, which includes the steps of: (a) reacting an acetonitrile of the general formula (I): wherein X , X , X , R and @ are each as defined above, with an alkylamine of the general formula (IV): R -NH2 (IV> wherein R is as defined above, to give an N-alkylacetamidine of the general formula (II): wherein X , X , X , R , R and @ are each as defined above; and (b) reacting the N-alkylacetamidine (II) with a nitrite derivative in the presence of an acid.
Bibliography:Application Number: CN19941015921