Injectable cystine small-molecular gel material and application thereof

• Main Authors: ZHONG XIANG, LOU HAOXIANG, ZHONG JINLIAN, WANG KEJUN, LUO XUZHONG, ZHONG JUPING, XIONG TUODONG, ZHANG HENG, FU HONGYU, JIA XINJIAN
• Format: Patent
• Language: Chinese; English
• Published: 03.12.2019
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC MACROMOLECULAR COMPOUNDS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS; VINEGAR; WINE; WORKING-UP

The invention discloses an injectable cystine small-molecular gel material and application thereof, belongs to the field of material chemistry and relates to a biomedical material. The gel material isprepared by the following method: firstly, N,N-dibenzoyl-L-cystine is used as a reaction substrate and modified with diethylene glycol to obtain a cystine gelator (DBC-DG); secondly, a polyethylene glycol is prepared from the gelator, distilled water is added, and shaking up is performed to obtain the gel material. Freeze-dried gel material has a 3D net or honeycomb-like structure. The method provided by the invention is convenient and easy to implement; and the prepared gel material has good biocompatibility and degradability in life bodies, can be applied to cell culture in tissue regeneration engineering field, can be used as a drug stent or carrier to be applied to clinical treatment and has great practical values. 一种注射型胱氨酸类小分子凝胶材料及其应用，属于材料化学领域，涉及一种生物医学材料。由以下方法制备而成：首先，将N,N′-二苯甲酰基-L-胱氨酸作为反应底物，以一缩二乙二醇对其加以修饰，得到一