METHODS AND COMPOSITIONS FOR GENE TRANSFER ACROSS VASCULATURE

• Main Authors: ASOKAN ARAVIND, ALBRIGHT BLAKE, MURLIDHARAN GIRIDHAR
• Format: Patent
• Language: Chinese; English
• Published: 29.11.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The disclosurealso provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo. 本公开提供了在氨基酸序列中包含修饰的AAV衣壳蛋白，以及包含经修饰的AAV衣壳蛋白的病毒衣壳和病毒载体。本公开还提供了将本公开的病毒载体和病毒衣壳体内施用至细胞或受试者的方法。