ONCOLYTIC VIRUS THERAPY

• Main Authors: BARTLETT DAVID, GUO ZONG, LIU ZUQIANG, FEIST MATHILDE
• Format: Patent
• Language: Chinese; English
• Published: 29.11.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The presently disclosed subject matter relates to tumor infiltrated T cells induced by oncolytic virus ("OV-induced T cells"), methods of making and using said OV-induced T cells for an adoptive T-cell therapy. The presently disclosed subject matter further relates to oncolytic viruses and armed oncolytic viruses, methods of making and using said oncolytic viruses, as well as pharmaceutical compositions and kits comprising said oncolytic viruses. 本文公开的主题涉及由溶瘤病毒诱导的肿瘤浸润T细胞("OV诱导T细胞")，制备和使用所述OV诱导T细胞用于过继性T细胞疗法的方法。本文公开的主题还涉及溶瘤病毒和武装溶瘤病毒，制备和使用所述溶瘤病毒的方法，以及包含所述溶瘤病毒的药物组合物和试剂盒。