AMPA RECEPTOR POTENTIATORS

• Main Authors: WARD SIMON, BESWICK PAUL, REUILLON TRISTAN, PENNICOTT LEWIS
• Format: Patent
• Language: Chinese; English
• Published: 29.11.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides compounds of the formula (I): wherein R1 and R2 are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia. 本发明提供了式(I)的化合物：其中R和R在说明书中定义，提供了包含所述化合物的药物组合物和用作药物的所述化合物。所述化合物增强AMPA受体功能，并且预期可用于治疗中枢神经系统病症，例如治疗与神经精神障碍(如精神分裂症)相关的抑郁障碍、情绪障碍和认知功能障碍。