Application of indazole piperidine pyrimidine compounds

• Main Authors: ZHU YUANYUAN, LIU GENYAN, FU SHIWEI, GU SHUANGXI, TANG JIAFAN, CHEN FEN'ER, XU ZHIQIANG, XIAO TING
• Format: Patent
• Language: Chinese; English
• Published: 29.11.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of medicines, and particularly relates to application of indazole piperidine pyrimidine compounds in preparation of anti-AIDS drugs. Anti-HIV activity testresults show that the indazole piperidine pyrimidine compounds defined by the invention have obvious inhibitory effect on HIV-1 virus, and the key index of HIV wild strain inhibitory activity of a plurality of compounds exceeds the listed drugs zidovudine, lamivudine and nevirapine, and the indazole piperidine pyrimidine compounds can be used for further development into anti-AIDS drugs. 本发明属于医药技术领域，具体涉及一种吲唑哌啶嘧啶类化合物在制备抗艾滋病药物中的应用。抗HIV活性测试结果表明，本发明所限定的吲唑哌啶嘧啶类化合物对HIV-1病毒具有明显的抑制作用，多个化合物的HIV野生株抑制活性这一关键指标超过上市药物齐多夫定、拉米夫定和奈韦拉平，可用于进一步开发为抗艾滋病药物。