Medical composition for treating colorectal cancer and application of medical composition

• Main Authors: MA WENKANG, LIU XUEYUAN, LUO JIANDONG, HONG WEI, LUO MINTAO, DU WEI, JIANG LILI, ZHENG JIACHENG
• Format: Patent
• Language: Chinese; English
• Published: 29.11.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a medical composition for treating colorectal cancer. The medical composition comprises arsenic trioxide, baicalin, radix rhizoma glycyrrhizae crude drug and honey, wherein thedosage of the arsenic trioxide is 3-7mg/kg/day, the dosage of the baicalin is 30-70mg/kg/day, the dosage of the radix rhizoma glycyrrhizae crude drug is 500mg/kg/day, the dosage of the honey is 300-700mg/kg/day, and the continuous administration day number of the medical composition does not exceed 7 days. The medical composition disclosed by the invention synergistically inhibits expression andtranscriptional activity of transcription factors SP1 in tumor cells, the radix rhizoma glycyrrhizae crude drug and the honey can reduce the occurrence of side effects, and metastatic tumor can be treated. 本发明公开了一种治疗结直肠癌的药物组合物，包括三氧化二砷、黄芩苷、甘草生药和蜂蜜；所述三氧化二砷的剂量为3-7mg/kg/天；所述黄芩苷的剂量为30-70mg/kg/天；所述甘草生药的剂量为500mg/kg/天，所述蜂蜜的剂量为300-700mg/kg/天。所述药物组合物的连续服药天数不超过7天。本发明的药物组合物协同抑制肿瘤细胞内转录因子SP1的表达及转录活性，且甘草生药和蜂蜜能够减低副作用的发生，治疗恶性肿瘤。