Synthetic method of 1-(2-chlorophenyl)-2-(1-chlorocyclopropyl)-3-hydrazino-2-propanol hydrochloride

• Main Authors: WANG WEI, LI BINGBO, WANG HONGXING, WANG XIAOFENG, LUO YIMING
• Format: Patent
• Language: Chinese; English
• Published: 26.11.2019
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the field of pesticide intermediate synthesis, and more specifically discloses a synthetic method of 1-(2-chlorophenyl)-2-(1-chlorocyclopropyl)-3-hydrazino-2-propanol hydrochloride. The synthetic method of 1-(2-chlorophenyl)-2-(1-chlorocyclopropyl)-3-hydrazino-2-propanol hydrochloride comprises following steps: 1-chloro-1-chloro-acetyl-cyclopropane is taken as a raw material, and is reacted with Grignard reagent-o-chlorobenzylmagnesium chloride to prepare 1-(2-chlorophenyl)-2-(1-chlorocyclopropyl)-3-chloro-2-propyl alcohol; and under alkali conditions, reaction with hydrazine hydrate is carried out, and acidifying is carried out to obtain the 1-(2-chlorophenyl)-2-(1-chlorocyclopropyl)-3-hydrazino-2-propanol hydrochloride. The synthesis method is simple and convenient in operation, and high in product yield and purity; and product is prepared into solid organic hydrochloride, so that difficult problems of hydrazino compounds such as the poor stability and difficult product purifying pr