Nickel-catalyzed imine ion and acetophenone nucleophilic reaction method

• Main Authors: PENG DAN, HOU ZITONG, LIU YIFAN, CUI SHIQI, ZHANG SHUO, WANG FENG, SONG ZIHE
• Format: Patent
• Language: Chinese; English
• Published: 19.11.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a nickel-catalyzed imine ion and acetophenone nucleophilic reaction method, which comprises: dissolving a 3-hydroxy-2-phenethyl-isoIndoline-1-one compound and an acetophenone-based compound in an organic solvent, adding a Ni (II) compound catalyst, carrying out a stirring reaction for 4-8 h at a temperature of 80-120 DEG C, extracting the reaction solution after the reaction, combining the organic layers, washing, drying, distilling to remove the solvent, and carrying out silica gel column chromatography on the residue to obtain the product. According to the present invention, by using the divalent nickel compound as the catalyst, the reaction conditions are mild, the disadvantage of strong acidic catalytic system and harsh conditions of the traditional method areavoided, and the reaction yield is high. 本发明涉及一种镍催化亚胺离子与苯乙酮的亲核反应方法，将3-羟基-2-苯乙基-异吲哚啉-1-酮类化合物与苯乙酮类化合物溶于有机溶剂中，加入Ni(II)化合物催化剂在80-120℃搅拌反应4-8h，将反应后的反应液进行萃取，合并有机层，洗涤，干燥，蒸除溶剂，残留物经硅胶柱层析，即得产品。本发明使用二价镍化合物作催化剂，反应条件温和，避免了传统方法强酸性催化体系、条件苛刻