Reducing [beta]-catenin expression to potentiate immunotherapy

• Main Authors: GANESH SHANTHI, ABRAMS MARC
• Format: Patent
• Language: Chinese; English
• Published: 15.11.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

Provided herein are methods and compositions for treating cancer, including cancer that is not responsive to immunotherapy. In one aspect, the methods of treatment comprise administering to the subject a therapeutically effective amount of a [beta]-catenin inhibitor and a therapeutically effective amount of an immunotherapeutic agent. Another aspect is directed to pharmaceutical compositions comprising a [beta]-catenin inhibitor for use in treating cancer, wherein the composition is administered in combination with an immunotherapeutic agent. Yet another aspect is directed to a method of potentiating the therapeutic effect of immunotherapy against a cancer using a [beta]-catenin inhibitor, such as a [beta]-catenin nucleic acid inhibitor molecule. 本文提供了用于治疗癌症的方法和组合物，所述癌症包括对免疫疗法无应答的癌症。在一个方面，所述治疗方法包括向受试者施用治疗有效量的β-连环蛋白抑制剂和治疗有效量的免疫治疗剂。另一方面涉及包含β-连环蛋白抑制剂的药物组合物，其用于治疗癌症，其中所述组合物与免疫治疗剂组合施用。另一方面涉及一种使用β-连环蛋白抑制剂诸如β-连环蛋白核酸抑制剂分子加强所述免疫疗法对癌症的治疗效果的方法。