Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer

• Main Authors: BELTRAN PEDRO J, COOKE KEEGAN, BEERS COURTNEY
• Format: Patent
• Language: Chinese; English
• Published: 15.11.2019
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to the use of oncolytic viruses (e.g., talimogene laherparepvec), either alone or in combination with immune checkpoint inhibitors (e.g., anti-CTLA-4, anti-PD-1, and anti-PD-L1 compounds such an antibodies) for the treatment of various types of cancer. In addition, the present invention relates to compositions and kits relating to such uses of oncolytic viruses, either alone or in combination with immune checkpoint inhibitors. 本发明涉及溶瘤病毒(例如，拉他莫金)单独或与免疫检查点抑制剂(例如，抗CTLA-4、抗PD-1和抗PD-L1化合物，如抗体)组合用于治疗各种类型的癌症的用途。另外，本发明涉及与溶瘤病毒单独或与免疫检查点抑制剂组合使用的此类用途相关的组合物和试剂盒。