Preparation method of VEGF and rhBMP-2 compounded dual-phase nanometer coating joint prosthesis

• Main Author: QU YANLONG
• Format: Patent
• Language: Chinese; English
• Published: 12.11.2019
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention provides a preparation method of VEGF and rhBMP-2 compounded dual-phase nanometer coating joint prosthesis, and relates to the field of a nanometer coating. The invention aims to solve the problems that a current artificial joint coating is not ideal in the effects of promoting interface angiogenesis, and accelerating osteoid formation and reconstruction to cause poor stability, particularly, an artificial joint stem slow release coating prepared through compounding a slow release system prepared through mixing ethylcellulose with polyethylene glycol, and recombinant human bone morphogenetic protein 2 cannot promote interface angiogenesis and is poor in the effect of inducing ossification so as to cause poor stability of an artificial joint, so that the risk that the artificial prosthesis generates complications of early loosening and the like is high, the revision surgery rate is high, and the long-time survival rate of the prosthesis is poor. VEGF165 and rhBMP-2, ethylcellulose and Macrogol 40